GLIS3 and diabetes mellitus: Similarly, genes ABCB11 (chromosome 2), ADCY5 (chromosome 3), CDKAL1 (chromosome 6), ANK1 (chromosome 8), GLIS3 (chromosome 9), and HKDC1 (chromosome 10) have been linked to various aspects of diabetes, including insulin release, glucose levels, β-cell function, and insulin resistance (Leong and Meigs, 2015; Roman et al., 2017).