Figure 1 presents a pathway. Evidence has accumulated indicating the significant relevance of low-grade inflammatory processes to cardiovascular disease, cancer and vascular risk factors (4, 7). Further, hs-CRP is a strong independent predictor of future cardiovascular events (6, 8). Cohort studies have shown that elevated CRP is associated with mortality and cardiovascular disease (CVD) events for patients with various CVD locations like coronary artery disease, cerebrovascular disease, peripheral artery disease, and abdominal aortic aneurysm (9). The gene discussed is CRP; the disease is peripheral arterial disease.