JAK2 and essential thrombocythemia: Particularly hemoglobin levels > 16.5 g/dl or > 16.0 g/dl (referring to men or women), or platelet counts > 450 GPT/l as major diagnostic criteria for MPN (polycythemia vera and essential thrombocythemia, respectively), according to the International Consensus Classification of 2022 (15), were only seen in a few cases with the presence of JAK2 p.V617F.