SLC9A3R1 (also known as NHERF1 and EBP50 is a scaffolding protein of ezrin), also enriched in RA-pEVs, is known to be involved in the regulation of smooth muscle cell migration and in atherosclerosis, a disorder with pain and fatigue as comorbidity symptoms (39, 40). This evidence concerns the gene EZR and rheumatoid arthritis.