In addition, the animal experiments with the Hanbikang Decoction have also proved that it can reduce the expression of RANKL and RANK in bone tissue and increase the expression of OPG by affecting the RANKL/RANK/OPG signaling pathway, so as to achieve the effect of anti-RA bone erosion and can be used to treat RA combined with OP. The gene discussed is TNFSF11; the disease is rheumatoid arthritis.