The gene S1PR4 showed the highest association with PTSD (−log10(p) 2.57), followed by TOP2A and TBXAS1 (−log10(p) 1.75), SULT1A1 (−log10(p) 1.58), S1PR1 (−log10(p) 1.44), and GABRG3 (−log10(p) 1.35). This evidence concerns the gene S1PR4 and post-traumatic stress disorder.