To date, there are two major types of UGT1A1 gene polymorphisms associated with neonatal hyperbilirubinemia, namely, alterations in the TATA box of the promoter, specifically changes in the repeat number of TA dinucleotide {UGT1A1*28 [A(TA)7TAA]}, and mononucleotide substitution mutations within the coding region [UGT1A1*6 (c.211G>T)]. This evidence concerns the gene UGT1A1 and Hyperbilirubinemia.