Consistent with previous studies (Yu et al., 2020; Yang et al., 2021), our findings suggest that the presence of UGT1A1 211G>A may mildly aggregate the severity of hyperbilirubinemia caused by ABO/Rh incompatibility, although the interaction effect was not significant, whereas UGT1A1 211G>A did not increase the risk of SHB combined with other clinical factors, consistent with findings in a study from Turkey (Halis et al., 2017). The gene discussed is UGT1A1; the disease is Hyperbilirubinemia.