The first two variants, p.Ala45Thr and p.Pro197His, were not associated with T2DM, whereas the latter two variants, p.Arg111Leu and c.206 + C, were associated with T2DM development by affecting the ability of NEUROD1 to bind E-box and active CBP/p300, respectively (Malecki et al., 1999; Malecki et al., 2003). The gene discussed is EP300; the disease is type 2 diabetes mellitus.