Regions like 12q13 and 12q24 contain many genes in which some of these loci play a role in immune signaling and insulin production, and they are evidenced to be associated with T1D genes such as ERBB3, CYP27B1, and SH2B3 (Cooper et al., 2012; Groop and Pociot, 2014). Here, INS is linked to type 1 diabetes mellitus.