Two sisters and the son of one of them, with no warts and moderate neutropenia, but severe autoimmune thrombocytopenia and autoimmune hemolytic anemia, had frameshift mutations in CXCR4 (C-X-C Motif Chemokine Receptor 4), a gene associated with WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis) (Maffucci et al., 2016; Abolhassani et al., 2020). Here, CXCR4 is linked to agammaglobulinemia.