Sixteen other subjects had autosomal dominant (AD) NFKB1 deficiency (Nuclear Factor Kappa B Subunit 1), and 7 others had NFKB2 (Nuclear Factor Kappa B Subunit 2) defects, both viewed as causative of this immune defect (Chen et al., 2013; Tuijnenburg et al., 2018; Li et al., 2021). Here, NFKB1 is linked to Alzheimer disease.