SERPINE2 is involved in the progression of some cancers, including lung cancer (Dokuni et al., 2020; Zhang et al., 2022a), renal cell carcinoma (Chen et al., 2023), esophageal squamous cell carcinoma (Zhang et al., 2020), colorectal cancer (Bergeron et al., 2010), pancreatic tumors (Buchholz et al., 2003), melanoma (Perego et al., 2018; Kang et al., 2022), and breast cancer (Wagenblast et al., 2015; Smirnova et al., 2016). Here, SERPINE2 is linked to renal cell carcinoma.