Our results signified that SERPINE1 was more expressed in BRCA, COAD, GBM, HNSC, kidney renal clear cell carcinoma (KIRC), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), esophageal carcinoma (ESCA), rectum adenocarcinoma (READ). This evidence concerns the gene SERPINE1 and glioblastoma.