KEGG analysis obtained herein demonstrated that SERPINEs may influence the tumorigenesis, progression, metastasis, and drug resistance of cancer by taking part in the processes of P53 signaling pathway (Lei et al., 2022; Asl et al., 2023; Fang et al., 2023) and HIF-1 signaling pathway (Fang et al., 2023). The gene discussed is TP53; the disease is cancer.