We found SERPINE1 was highly expressed in cancer tissues in BRCA, GBM, brain lower grade glioma (LGG), pancreatic adenocarcinoma (PAAD), ESCA, STAD, COAD, READ, testicular germ cell tumors (TGCT), Thymoma (THYM), Lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), KIRC, and HNSC. Here, SERPINE1 is linked to diffuse large B-cell lymphoma.