Besides, SERPINE2 expression positively linked to the TMB in four cancers, including TGCT, KIRP, KIRC, and KICH, while it negatively related to the TMB in THCA, STAD, PAAD, LUSC, LIHC, LGG, HNSC, ESCA, COAD, and BLCA. Here, SERPINE2 is linked to cancer.