Our results signified that SERPINE1 was more expressed in BRCA, COAD, GBM, HNSC, kidney renal clear cell carcinoma (KIRC), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), esophageal carcinoma (ESCA), rectum adenocarcinoma (READ). The gene discussed is SERPINE1; the disease is thyroid gland carcinoma.