Inactivation of the hp0231 gene also results in (i) impaired translocation of the H. pylori CagA protein (cytotoxin-associated protein A), which is associated with gastric carcinoma in the host, (ii) the loss of H. pylori-induced production of interleukin 8 (IL-8) (one of the major mediators of the inflammatory response), and (iii) increased sensitivity of H. pylori cells to oxidative stress (Lester et al., 2015). This evidence concerns the gene CXCL8 and gastric carcinoma.