BRCA1 and pancreatic neoplasm: Mutations in BRCA2 also cause a 5–10% lifetime risk for pancreatic cancer, while BRCA1 carriers might have two to four times risks compared to non-carriers (van Asperen et al., 2005; Ferrone et al., 2009; Mocci et al., 2013; Zhen et al., 2015; Roberts et al., 2016).