In contrast to previous findings that diabetes or high glucose increases Nav1.7 and Nav1.8 in DRG neurons, the current study does not find changes in SR TTX-S current or TTX-R current following high glucose treatment (Hong et al., 2004; Chattopadhyay et al., 2008; Sun et al., 2012; Hu et al., 2016; Nakatani et al., 2020). Here, SCN9A is linked to diabetes mellitus.