LRRK2 and Parkinson disease: Increased tLRRK2 in the frontal cortex in sporadic PD cases, conflicting changes of tLRRK2 l in cerebrospinal fluid (CSF) in sporadic PD cases, elevated pS1292-LRRK2 in urinary EVs in but deceased pS935-LRRK2 in PBMCs among LRRK2-G2019S carriers, and increased pT73-Rab10 in neutrophils in idiopathic PD and LRRK2-G2019S carriers have been reported (Cho et al., 2013; Fraser et al., 2016; Fan et al., 2018; Mabrouk et al., 2020; Padmanabhan et al., 2020).