iPSC-derived neural cells bearing LRRK2 G2019S and fibroblasts derived from PD patients carrying LRRK2 G2019S show mitochondrial impairment, suggesting that LRRK2 pathogenesis might involve mitochondrial dysfunction (Mortiboys et al., 2010; Sanders et al., 2014). This evidence concerns the gene LRRK2 and Parkinson disease.