IDH1 and central nervous system cancer: The interest of neuro-oncology in the development of IDH inhibitors in different disease settings (for example high-risk patients or enhancing high-grade gliomas) and/or in association with other anti-cancer agents is very high: several phase I trials are underway, aiming to evaluate the efficacy of vorasidenib in combination with tumor specific peptide vaccine (NCT05609994) and in combination with pembrolizumab (NCT05484622).