In lung cancer cells, treatment of A549 (human lung adenocarcinoma cell) and H1299 (non-small cell lung carcinoma cell) with eATP revealed the formation of F-actin-rich filamentous foot-like protrusions on the plasma membrane, suggesting that P2X7 may be associated with cell spreading (63). This evidence concerns the gene P2RX7 and non-small cell lung carcinoma.