MAPK8 and neoplasm: In conclusion, stimulation of the P2X7 receptor can activate the P13K/AKT signaling pathway (87, 90), decrease GSK3β activity, activate Wnt/β-catenin, increase VEGF level (90), activate JNK and Rho, and increase MMP2 expression (37), all of which are involved in tumor cell migration and invasion.