MAPK8 and neoplasm: P2X7 activation in various cell types, including macrophages, lymphocytes (such as T lymphocytes and B lymphocytes), glial cells (microglia and astrocytes), and tumor cells (including most human tumor cells such as breast cancer, gastric cancer, colorectal cancer, and lung cancer cells), triggers the activation of associated signaling pathways like MAPK, JNK, and ATK.