CD274 and neoplasm: We choose CD8 and FOXP3 as surrogate markers for tumour-infiltrating lymphocytes (TILs) whose prognostic role is already known (42), since the lymphocyte infiltrate is heterogeneous, containing both helper and cytotoxic lymphocytes and regulatory-inhibitory lymphocytes (43), and as recent studies have shown direct correlations between TILs, programmed death-1 ligand (PD-L1), CD8, and FOXP3 in early TNBC (44).