Tissue editing techniques include synergistic combinations of bioactive drugs, such as metronomic low-dose chemotherapies, transcriptional modulators, i.e., pioglitazone, interferon-α, dexamethasone or all-trans retinoic acid (ATRA) and cyclooxygenase-2 (COX-2) inhibitors, and may induce long-term tumor control, objective response, even continuous complete remission (cCR) in r/r neoplasias (21–23, 25–28). Here, PTGS2 is linked to neoplasm.