Specific overexpression of elongation of very long-chain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) in mesenchymal gastric cancer cells, both involved in PUFAs synthesis, makes cancer cells particularly susceptible to ferroptosis (Lee et al., 2020) (Table 1). The gene discussed is ELOVL5; the disease is gastric cancer.