Though IFN-γ secretion by T cells induced by ferroptosis effectively eliminates tumour cells, it can also elevate programmed death ligand-1 (PD-L1) levels, triggering IFN-γ-related adaptive immune resistance (Dorand et al., 2016; Li et al., 2021) (Figure 2; Table 2). This evidence concerns the gene CD274 and neoplasm.