ACSL4 and hepatocellular carcinoma: In a mature toxic injury model, intervention in ACSL4-dependent ferroptosis notably suppressed HCC progression, likely due to reduced fibrosis in the absence of ACSL4 (Tsurusaki et al., 2019; Li et al., 2020a; Luo et al., 2020; Qi et al., 2020) (Table 2).