GPX4, the only member of the GPX protein family capable of converting phospholipid hydroperoxides into phosphatidyl alcohols, prevents lipid peroxidation, thus restraining ferroptosis and supporting tumour growth (Ursini et al., 1982; Brigelius-Flohé and Maiorino, 2013; Seibt et al., 2019; Brigelius-Flohé and Flohé, 2020). This evidence concerns the gene GPX4 and neoplasm.