In patients with KRAS-mutant lung adenocarcinoma (LUAD), SLC7A11 mediates cystine uptake, decreases ROS production and thus promotes lung adenocarcinoma proliferation and migration (Hu et al., 2020; Liu et al., 2020; Chen et al., 2021; Lou et al., 2021). This evidence concerns the gene KRAS and lung adenocarcinoma.