The overexpression of EGFR was observed to be a causative agent of cancer progression first identified in squamous cell carcinomas (SCCs) (Cowley et al., 1986; Olofsson et al., 1986) and then in sarcomas (Gusterson et al., 1984), non-small cell lung carcinoma (NSCLC) (Veale et al., 1987), and malignant gliomas (Wong et al., 1987). This evidence concerns the gene EGFR and cancer.