TXNIP and type 1 diabetes mellitus: John Chambers et al. followed 25,372 Indian Asians and Europeans and found that methylation of ABCG1, PHOSPHO1, SOCS3, SREBF1 and TXNIP in the blood was associated with a higher risk of future T2DM; in type 1 diabetes Methylation of ABCG1, PHOSPHO3, SOCS1, SREBF2 and TXNIP sites was found (Chambers et al., 2015b).