Systemic inflammation has now been incorporated into the definition of cachexia as “complex metabolic syndrome associated with underlying diseases characterized by muscle loss with or without fat loss.” Epidemiological studies showed that CRP is correlated with the increased risk of malignant tumors, anorexia-cachexia syndrome, and poor prognosis, including tumor size, tumor recurrence, lymph node metastasis, and distant metastasis [48, 49]. This evidence concerns the gene CRP and metastatic malignant neoplasm in the lymph nodes.