NLRP3 and Intervertebral disk degeneration: Moreover, previous studies have also demonstrated that PRP-Exos can reduce the expression of inflammatory mediators and apoptosis factors in vivo and can promote the autophagic degradation of NLRP3 by increasing the ubiquitination level of NLRP3 and reducing the production levels of IL-1β and Caspase-1 [202], thereby alleviating intervertebral disc degeneration.