For example, to gain further insights into drug resistance to combinational immunotherapy, Osnat Bartok et al. performed ribosome profiling in melanoma cells and revealed that prolonged interferon-γ (IFNγ) treatment induced IDO1 expression, depleted tryptophan (TRP), and led to accumulation of kynurenine, which resulted in ribosome accumulation and stalling downstream or at the tryptophan codon. The gene discussed is IFNG; the disease is melanoma.