Glycerol-3-phosphate dehydrogenase 1 (GPD1), an enzyme that links glycolysis to lipid biosynthesis by converting dihydroxyacetone phosphate(DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate and NAD+, is exclusively expressed in brain tumor stem cells and is a potential therapeutic target in brain cancer because of its role in modulating cellular metabolism [86] (Fig. 3). The gene discussed is GPD1; the disease is brain cancer.