A recent study by Zhang’s group found that circ-SMO (hsa_circ_0001742), a newly discovered circRNA enriched in GBM cancer stem cells (CSCs), was validated as the translation template for a novel 193aa-length variant (SMO-193aa) of the G protein-coupled-like receptor smoothened (SMO, receptor for the HH ligands) by multiple experimental procedures including polysome profiling. The gene discussed is SMO; the disease is glioblastoma.