Further experiments demonstrated that HOXB-AS3 encodes a 55-amino acid (aa) peptide and that this peptide, not the lncRNA, exerts its tumor-suppressive role by competitively impairing the binding of splicing factor heterogeneous nuclear ribonucleoprotein A1(hnRNP A1) to PKM exon 9, favoring the formation of PKM1 over PKM2. The gene discussed is PKM; the disease is neoplasm.