Similarly, gastric cancer cells acquire a glycolysis-dependent phenotype by upregulating the expression of glycolytic enzymes, including Hexokinase (HK) 1, HK2, Hexokinase Domain Containing (HKDC1), and Pyruvate Dehydrogenase Kinase 1 (PDK1) [84] (Fig. 3). The gene discussed is PDK1; the disease is gastric cancer.