In contrast, in hepatocellular carcinoma (HCC), using multi-omics data deposited in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, the authors found that METTL3 and METTL14 played opposite roles in regulating multiple signaling pathways via catalyzing m6A modification of target mRNAs [134]. This evidence concerns the gene METTL14 and hepatocellular carcinoma.