In contrast, in hepatocellular carcinoma (HCC), using multi-omics data deposited in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, the authors found that METTL3 and METTL14 played opposite roles in regulating multiple signaling pathways via catalyzing m6A modification of target mRNAs [134]. The gene discussed is METTL3; the disease is hepatocellular carcinoma.