In addition, Wherry et al. examined the phenotype of tumour-infiltrating lymphocytes (TILs) in glioma specimens and found that they were enriched in CD95, D-1, PD-L1, CTLA-4, LAG3, and TIM-3, which clearly suggests immune depletion of T cells [19]. The gene discussed is CTLA4; the disease is central nervous system cancer.