The mosaic architecture, infiltrative appearance, and targetoid HBP in the mass exhibited sensitivities of 88.89% (95% CI: 75.90–96.30), 77.78% (95% CI: 62.90–88.80), and 75.56% (95% CI: 60.50–87.10), specificities of 56.58% (95% CI: 44.70–67.90), 46.05% (95% CI: 34.50–57.90), and 39.47% (95% CI: 28.40–51.40) and AUC of 0.727 (95% CI: 0.639–0.804), 0.619 (95% CI: 0.526–0.706), 0.575 (95% CI: 0.482–0.665) for the prediction of the HCC with Ki-67 ≥ 50%, respectively. This evidence concerns the gene MKI67 and hepatocellular carcinoma.