For Ki-67 ≥ 20%, univariate analysis suggested that absence of nonperipheral washout (p = 0.062), presence of mosaic architecture (p = 0.092), presence of rim APHE (p = 0.020), presence of targetoid restriction (p = 0.020), and presence of peritumoral enhancement (p = 0.026)were potential differential factors for the prediction of HCC with Ki-67 ≥ 20%. The gene discussed is MKI67; the disease is hepatocellular carcinoma.