CD8A and neoplasm: Additionally, prior to neoadjuvant treatment, a high infiltration of CD8 cells (≥ 25) in the tumour microenvironment increases the likelihood of achieving a pCR in the breast by approximately 4-fold compared to patients with low CD8 infiltration [OR (95% CI): 4.2 (1.02–17.43), p: 0.047].