To address whether the population context (i.e., location of a cell within a population) can modulate IFN-mediated signaling, we exploited our previously described human-colon carcinoma T84 cells expressing a fluorescent protein (fp) under the transcriptional control of the interferon-stimulated gene (ISG) MX1 promoter (T84-prom-Mx1-fp) (Doldan et al, 2022a). The gene discussed is MX1; the disease is colon carcinoma.