CBF-AML are characterized by either the chromosomal translocation t(8;21)(q22;q22.1) or rearrangement inv(16)(p13.1q22)/t(16;16)(p13.1;q22), respectively leading to the translation of aberrant fusion proteins RUNX1::RUNX1T1 and CBFB::MYH11[5–7]. The gene discussed is CBFB; the disease is acute myeloid leukemia.