The results from the present study indicated that transcription factor KLF15 was found to upregulate LINC00689 via binding to its promoter, then the upregulated LINC00689 could enhance the stability of LATS2 mRNA through interacting with PTBP1 protein, thereby inhibiting CRC development by repressing the activation of YAP1/β-catenin pathway (Fig. 10). Here, PTBP1 is linked to colorectal carcinoma.