Collectively, these data suggest that (1) cholestatic liver injury promotes the recruitment of neutrophils and macrophages into the liver, (2) the primary source of TRAIL in DDC diet-induced cholestasis is the macrophage compartment, and (3) that deletion of TRAIL in myeloid cells favored the persistence and retention of specific subsets of neutrophils and macrophages within the liver. This evidence concerns the gene TNFSF10 and cholestasis.