As SAM68 interacts with the Ras effector Grb2 via its SH3 domains35 (also enriched in EML4-Alk-expressing Beas2B cells (Extended Data Fig. 5e–h)) and is associated with several cancer types36, we explored the function of SAM68 in EML4-Alk granules. Here, GRB2 is linked to cancer.