ALK and cancer: YB-0158 affects the Wnt/β-catenin and NF-κB transcriptional programs and the gene expression of several cell cycle markers, proliferation inhibitors and cancer markers37,38, but the short timescales (1 h) in which we see effects on Ras activation and downstream Erk signaling (Fig. 4h and Extended Data Fig. 7c,d) support the notion that YB-0158 acts by disrupting SAM68’s localization within EML4-Alk granules.