The scRNA-seq results from 4-month-old organoids demonstrate that the PT organoids are dominated by two major cell populations, one shows high expression of stem/progenitor cell markers like SOX2 and PAX6 (paired box 6), and the other express the immature neuron marker DCX and the astrocyte marker FABP7 (Fig. 2d), indicating a proneural-like tumor cell feature. Here, SOX2 is linked to neoplasm.