CD4 and lymphoma: Furthermore, the killing activity by cytotoxic CD4 T cells was also proved against autologous lymphoblastoid cell lines (LCLs)27, as well as pre-endemic Burkitt lymphoma cells28, in consequence, further in vitro studies are required to explore if this specific cells in our pediatric population might be also able to restrict EBV-mediated transformation, and, ultimately, EBV-associated lymphomas.