Given that IRS1 and IRS2 are known to activate key signaling pathways involved in cancer progression, such as the PI3K/AKT and ERK/MAPK pathways, we also examined the protein levels of AKT phosphorylation (pAKT)(S473) and ERK phosphorylation (pERK)(T202/204). The gene discussed is AKT1; the disease is cancer.