TNF and astrocytoma (excluding glioblastoma): Relative to oligodendrogliomas, in IDH-mutant astrocytomas, immune cell clusters were enriched for gene sets associated with inflammatory response, IFNα response, IFNγ response and TNFα signaling via NFκB; whereas tumor cell clusters exhibited minimal enrichment for immune related molecular networks (Fig.1b; Supplementary Data 2).