The majority of the ATRX-mut astrocytomas exhibited enrichment of gene ontology (GO) terms associated with immune-related pathways, including activation of innate immune response, PRR activation, and response to IFNα and β (Fig. 1a; Supplementary Fig. 1a, b, Supplementary Data 1). The gene discussed is ATRX; the disease is astrocytoma (excluding glioblastoma).