For instance, one study investigating the effects of ATRX loss in the context of IDH and TP53 mutations concluded that ATRX loss confers an immunosuppressive state as evidenced by upregulated secretion of relevant cytokines and chemokines (CXCL8, IL6, CXCL3, and CSF2) and increased tumor growth24. This evidence concerns the gene ATRX and neoplasm.