For a thorough analysis of the skin tumor-specific transcriptome, we conducted single-cell RNA sequencing (scRNA-seq) on total T cells isolated from MF skin lesions and blood of MF patients with blood involvement, as well as T cells from healthy individuals, all pre-enriched using fluorescence-activated cell sorting (FACS) for live CD45+/CD3+ T cells. Here, PTPRC is linked to mycosis fungoides.