The TF most enriched over TE-eQTLs in normal tissues was ZNF274, a Krüppel-associated box (KRAB) domain-containing zinc-finger protein (KZFP), whereas the most enriched over tumor TE-eQTLs was TRIM28, the master corepressor that is recruited by the KRAB domain of many TE-binding KZFPs and serves as a scaffold for a heterochromatin-inducing complex capable of repressing TEs via histone H3 Lys9 trimethylation (H3K9me3), histone deacetylation and DNA methylation16,17. Here, TF is linked to neoplasm.