CD8+ T cells play an important role in the immune system’s defense against pathogens and tumors [71], while CD4+ T cells, including subpopulations such as helper T cells 1 (Th1), Th17, regulatory T cells (Tregs) and so on, mainly involved in antimicrobial immunity, autoimmunity, and tumor immunity [72, 73]. Here, CD8A is linked to neoplasm.