SHH and neoplasm: Interestingly, CPT treatment significantly upregulated SHH, an oncogene that promotes the progression and metastasis in PDAC [35, 36], but downregulated CCNG2, a key tumor suppressor gene in PDAC [37, 38] (Fig. S5E), suggesting a pro-tumor activity of Vitamin D in MiaPaca2 cells without epigenetic priming.