CREG1 and embryonal carcinoma: Studies have revealed that CREG1 could induce differentiation as a soluble factor in embryonal carcinoma cells; overexpression of CREG1 augmented retinoic acid‐induced differentiation of embryonal carcinoma cells into the neuronal lineage; CREG1 expression was induced during the differentiation of human vascular smooth muscle cells; using gain‐ and loss‐of‐function analysis, we have also shown that CREG1 induced cardiomyogenic differentiation from embryonic stem cells.14, 28