The TA muscles of Creg1MKO mice were injected with AAV‐vector or AAV‐shC‐Cbl, silencing C‐CBL (P < 0.01) in the skeletal muscles of Creg1MKO mice significantly improved muscle regeneration induced by CTX injury (P < 0.01). The gene discussed is CBL; the disease is cerebrotendinous xanthomatosis.