Knockout of ATXN2, FBXO32 or PRSS23, resulted in an over expression of ANGPTL4 in fibroblast like cells (fold change range 4.12–4.83; adjusted P < 1.01E-24), which is noteworthy given that ANGPT2, which encodes for angiopoietin, is critically involved in the development of Schlemm’s canal, with monogenic variants known cause congenital glaucoma through elevated IOP [37–39]. This evidence concerns the gene ANGPTL4 and congenital glaucoma.