Many POAG-associated loci have been identified through genome-wide association studies (GWAS) [9], with loci encompassing Caveolin 1 and 2 (CAV1/CAV2), Transmembrane and coiled-coil domain-containing protein 1 (TMCO1), cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), ATB binding cassette subfamily A member 1 (ABCA1), actin filament associated protein 1 (AFAP1), GDP-mannose 4,6-dehydratase (GMDS), Forkhead Box C1 (FOXC1), thioredoxin reductase 2 (TXNRD2), and Ataxin 2 (ATXN2) [10–13]. The gene discussed is AFAP1; the disease is open-angle glaucoma.