There were five statistically significantly (P < 10−6) upregulated DEGs (CXCL11, CST1, LCE1C, OASL, CD70) and three downregulated DEGs (STEAP4, CCN5, C1orf87); however, these genes have not previously been found to cause TMC dysfunction or POAG. The gene discussed is CST1; the disease is open-angle glaucoma.