In LA3IK-treated samples, a significant downregulation was observed among genes central in cancer-related inflammation and epithelial-mesenchymal transition (EMT), exemplified by the reduced expression of IL1B, CXCL-8, matrix metalloproteinase 1 (MMP-1), and Zeb-1 (Fig. 2A). The gene discussed is ZEB1; the disease is cancer.