TRIP12 has a plethora of targets including poly(ADP-ribose) polymerase 1 involved in DNA repair and transcription regulation (35), the RING finger E3 ligase RNF168 involved in DNA damage repair (36), substrates of the ubiquitin fusion degradation pathway (37), the lysosomal enzyme glucocerebrosidase involved in sphingolipid metabolism (38), and the tumor-suppressor FBW7 (39). Here, RNF168 is linked to neoplasm.