Although inhibition of both mTORC1 and mTORC2 by AZD8055 led to cell death in all NPC cell lines we tested, the PI3K/mTOR inhibitor LY294002 and mTORC1 inhibitor rapamycin exhibited limited or no cytotoxic effects in most NPC cells, except for 5-8F and 6-10B (Fig. 6B). This evidence concerns the gene MTOR and nasopharyngeal carcinoma.