MUC2 and Cowden disease: To gain insight into where these differences lie, we compared the mean relative abundances of individual sialylated glycans between healthy, mild/remission CD, and active CD HF MUC2 (Figs. 6D and S7, A–F), finding that healthy and mild/remission CD samples largely mirrored each other, while active CD samples showed increases in specific isomers of tri-, tetra-, and pentasaccharides containing a Hex, Neu5Ac, and one or more HexNAcs (Fig. 6D).