We found 43 patients out of 1122 harboring mutations in these genes: 65,1% were male and 30,2% were female and the Glioblastoma Neoplasma Histologic Type (46,5%), histological grade 4 (G4, 46,5%), Pro Neural transcriptome subtype (32,6%), IDH wild type (58,1%), with methylated MGMT promoter (53,5%) and short overall survival (<15 months) were the features more frequent associated with patients harboring mutations in differentially regulated Matrisome associated proteins (Supplemental Table S8). Here, MGMT is linked to glioblastoma.