CD44 and central nervous system cancer: Another important finding in this work was the down regulation of the Matrisome Associated ECM-affiliated protein Glypican-1, a prognostic biomarker in glioma that belongs to the family of heparan sulfate proteoglycans (HSPGs) (62) that is overexpressed in glioma (63) and has been linked to a poor prognosis in GBM patients (64).