We demonstrated this activity with the parasite linesCS2, modeling the severe pathology of placental malaria, and ItG,which binds ICAM-1 and is associated with deadly cerebral malaria.We finally confirmed the activity of our nanoparticles in preventionand reversal of ItG iRBCs binding to ICAM-1 overexpressing human umbilicalvein endothelial cells (HUVECs), after tumor necrosis factor α(TNF-α) stimulation. The gene discussed is TNF; the disease is cerebral malaria.