This protein is translocated to the iRBC surfaceto mediate specific interactions with endothelial receptors includingheparan sulfate,7,8 chondroitin sulfate A (CSA),9 and intercellular adhesion molecule 1 (ICAM-1),10 among others.6 TheCSA interaction can cause placental malaria, while the ICAM-1 interactionis associated with cerebral malaria; both represent severe healthrisks for the unborn child and mother and cerebral malaria patient,respectively. The gene discussed is ICAM1; the disease is cerebral malaria.