A recent study showed that cell-cycle-related and expression-elevated protein in tumor (CREPT) and p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A (p15RS) regulated cell proliferation and the cell-cycle transition in chicken embryo fibroblast cells by mediating the transcription of Wnt/β-catenin signaling pathway downstream regulatory genes [34]. The gene discussed is CDKN2B; the disease is neoplasm.