The QTLs of SCC neighbor 22 RMRGs, including CPSF1, TET3, EIF3G, CFI, TET2, METTL16, NUDT21, LRPPRC, YTHDF3, ALKBH5, METTL4, IGF2BP1, EIF3A, PUS7, CBLL1, SRSF2, CSTF1, NSUN7, DNMT3B, VIRMA, DNMT3A, and YTHDC1. The RMRGs that identified the QTLs for clinical mastitis included LRPPRC, YTHDF3, EIF3A, EIF3H, METTL1, NSUN7, VIRMA, WTAP, NSUN4, and YBX1. Furthermore, a large number of immune-related QTLs also neighbor RMRGs in pig and sheep (Supplementary Figure S1). The gene discussed is DNMT3B; the disease is mastitis.